Translation of "be most worrying" into Russian

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Indeed, it is in highly commercialised fields such as biomedicine that the merging of public and proprietary science is most worrying. Это в высоко коммерциализованных областях, таких как биомедицина, слияние общественной и частной науки вызывает наибольшее беспокойство.
What is most worrying isn’t the vote manipulation and intimidation that pushed Putin’s victory from something like a still-decisive (speculative) 45% to the more convenient 65%... it’s the political atmosphere in Russia during off-election time. Самое тревожное в сложившейся ситуации – это не манипуляции и запугивание, которые позволили Путину получить вместо все равно весомых (предположительно) 45% голосов более удобные ему 65%, а политическая атмосфера в России в свободное от выборов время.
I would be most grateful to have your reply as soon as possible. Я был бы чрезвычайно благодарен, если бы Вы ответили нам как можно скорее.
Most worrying, it comes at the precise moment when more thoughtful, measured consideration of the U.S.-Russia relationship is sorely needed. Наибольшую тревогу вызывает то, что эта точка зрения сложилась как раз в тот момент, когда остро необходимо вдумчивое и взвешенное рассмотрение российско-американских отношений.
We would be most grateful to have your reply as soon as possible. Мы были бы чрезвычайно благодарны, если бы Вы ответили нам как можно скорее.
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